To severely damage someone's reputation or livelihood through excessive and malicious slander; to utterly destroy a person through calumny.
面对那些无端的指责和恶意中伤，他感到身心俱疲，仿佛遭受了铄金毁骨般的打击。
Facing those groundless accusations and malicious slanders, he felt utterly exhausted, as if suffering a blow that could melt metal and destroy bones.
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