All is lost; everything is over; to feel utterly defeated and hopeless.
他多年来的努力付诸东流，面对这个结果，他感到万事俱休，几乎失去了重新开始的勇气。
After years of effort came to nothing, facing this outcome, he felt all was lost, almost losing the courage to start anew.
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All is lost; everything is over; to feel utterly defeated and hopeless.