To suffer profound harm or deep pain, as from a severe disaster; to be damaged to the very core.
这次突如其来的变故对他的家庭来说，简直是剥床及肤的打击。
This sudden unforeseen change was a devastating blow to his family, causing profound and widespread suffering.
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To suffer profound harm or deep pain, as from a severe disaster; to be damaged to the very core.