Old and infirm; aged, weak, and disabled; frail and sickly with disabilities.
他的一生饱经风霜，年迈时更是疲癃残疾，生活多有不便。
His life was full of hardships, and in his old age, he became frail and disabled, experiencing many inconveniences.
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Old and infirm; aged, weak, and disabled; frail and sickly with disabilities.