A boil in the eye, a thorn in the flesh; refers to someone or something that is deeply hated or detested, a constant source of annoyance and pain.
那个总是喜欢背后说人闲话的同事，简直是团队中的眼中疔，肉中刺，让大家都很不舒服。
That colleague who always gossips behind people's backs is truly a boil in the eye and a thorn in the flesh for the team, making everyone very uncomfortable.
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