Refers to a complete and insurmountable separation, often between people who wish to be together, implying that reunion is impossible, like the separation between heaven and earth.
自从他远走他乡，音信全无，我们之间就如同仙凡路隔，再难相见
Since he went far away with no news, it has been like the paths of immortals and mortals are separated between us, making it difficult to meet again.
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