To achieve great success through persistent effort, even when facing significant disadvantages or initial handicaps.
小明家境贫寒，但他凭着一股跛行千里的韧劲，终于考上了理想的大学。
Despite his humble background, Xiao Ming, with the tenacity of "a lame person traveling a thousand li" (persevering against all odds), eventually gained admission to his dream university.
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