Great changes over time; the vicissitudes of life; drastic transformations.
世事变幻莫测，回首往昔，才感慨这几十年来的陵谷沧桑。
Worldly affairs are unpredictable; looking back, one truly laments the drastic transformations of these past decades.
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Great changes over time; the vicissitudes of life; drastic transformations.