Lack self-respect; have no self-regard; act without self-respect.
他因为总是熬夜不休息，完全不知自爱，结果身体越来越差。
He always stays up late without resting, completely disregarding his own well-being, and as a result, his health is getting worse.
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Lack self-respect; have no self-regard; act without self-respect.