To die with unfulfilled ambitions or aspirations; to pass away before achieving one's goals or dreams.
他毕生致力于科学研究，却在重大突破前夕撒手人寰，令人惋惜他赍志以殁。
He dedicated his entire life to scientific research, but passed away just before a major breakthrough, leaving many to lament that he died with unfulfilled aspirations.
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