To be utterly ruined, with one's family scattered or dead and their home destroyed; describes a tragic state of utter desolation and ruin for a family.
经历了一场无情的灾祸后，那个曾经和睦的家庭变得人亡家破，令人痛心不已
After experiencing a relentless calamity, that once harmonious family was utterly ruined with members gone or scattered, which was heartbreaking to witness.
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