Persistent malicious slander or false accusations can utterly destroy a person's reputation and well-being, even to the point of causing physical or emotional ruin; numerous calumnies can confuse right and wrong.
尽管他为人正直，但面对恶意揣测和众毁销骨的攻击，也感到心力交瘁。
Despite his integrity, he felt utterly exhausted facing malicious speculation and calumnies that seemed to melt his very bones.
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