To lose one's senses completely; to be utterly deranged and act wildly or absurdly, often implying depraved or heinous conduct.
那个小偷为了盗取财物，竟然纵火烧毁了别人的家园，真是病狂丧心。
That thief, in order to steal valuables, even set fire to someone's home; it was truly utterly deranged and heinous.
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