To compare a trifle with a heavy weight; to be at an absolute disadvantage due to extreme disparity in power or scale.
这家初创公司想要在市场上和那些行业巨头竞争，简直是以铢称镒，需要付出比常人多百倍的努力才能获得一线生机。
For this startup company to compete with the industry giants in the market is like comparing a trifle with a heavy weight; they need to put in a hundred times more effort than ordinary people to have a glimmer of hope.
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